Shiro Murata Selected Research

Deltaretrovirus Infections (BLV Infection)

1/2022	Estradiol-induced immune suppression via prostaglandin E2 during parturition in bovine leukemia virus-infected cattle.
1/2021	A TLR7 agonist activates bovine Th1 response and exerts antiviral activity against bovine leukemia virus.
1/2019	Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection.
1/2018	Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection.
1/2017	Immune exhaustion during chronic infections in cattle.
2/2015	Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection.
7/2013	Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro.
1/2013	Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus.
5/2012	Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection.
9/2011	Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade.

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Shiro Murata Research Topics

Disease

11	Neoplasms (Cancer) 01/2022 - 01/2014
11	Disease Progression 01/2022 - 05/2012
10	Deltaretrovirus Infections (BLV Infection) 01/2022 - 09/2011
9	Persistent Infection 12/2021 - 09/2011
9	Infections 01/2020 - 05/2012
7	Marek Disease (Marek's Disease) 01/2022 - 09/2007
5	Melanoma (Melanoma, Malignant) 01/2022 - 01/2016
5	Paratuberculosis (Johne's Disease) 01/2020 - 01/2016
2	Cattle Diseases (Bovine Diseases) 01/2022 - 07/2014
2	Bacterial Infections (Bacterial Infection) 01/2020 - 01/2019
2	Chronic Disease (Chronic Diseases) 10/2019 - 01/2017
1	Carcinogenesis 11/2021
1	Horse Diseases (Horse Disease) 01/2020
1	Osteosarcoma (Osteogenic Sarcoma) 01/2020
1	Inflammation (Inflammations) 02/2019
1	Virus Diseases (Viral Diseases) 01/2019
1	Anaplasmosis 01/2017
1	Sarcoma (Soft Tissue Sarcoma) 01/2017
1	Lymphocytosis 03/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2016
1	Lymphoma (Lymphomas) 08/2014
1	Coinfection 10/2013
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 06/2013
1	Babesiosis (Piroplasmosis) 10/2012
1	Disease Resistance 08/2012

Drug/Important Bio-Agent (IBA)

11	LigandsIBA 02/2021 - 09/2011
10	B7-H1 AntigenIBA 01/2022 - 09/2011
5	AntibodiesIBA 01/2022 - 01/2016
5	Dinoprostone (PGE2)FDA Link 01/2022 - 01/2018
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2011
5	CytokinesIBA 01/2021 - 08/2012
4	AntigensIBA 01/2017 - 01/2014
3	Monoclonal AntibodiesIBA 02/2021 - 01/2017
3	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2020 - 01/2018
3	Messenger RNA (mRNA)IBA 02/2015 - 05/2012
2	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2016
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 01/2020
2	VaccinesIBA 12/2020 - 06/2016
2	Blocking AntibodiesIBA 01/2018 - 01/2017
2	DNA (Deoxyribonucleic Acid)IBA 05/2014 - 09/2007
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2022
1	Interleukin-2 (IL2)IBA 12/2021
1	Transcription Factors (Transcription Factor)IBA 11/2021
1	Oncogene Proteins (Oncogene Protein)IBA 11/2021
1	Protein SIBA 11/2021
1	Biological ProductsIBA 01/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2021
1	vesatolimodIBA 01/2021
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2019
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2019
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2019
1	ProstaglandinsIBA 01/2019
1	Meloxicam (Mobic)FDA LinkGeneric 01/2019
1	Antiviral Agents (Antivirals)IBA 01/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2018
1	Tuberculin (PPD)IBA 01/2018
1	Immune Checkpoint ProteinsIBA 01/2017
1	PerforinIBA 03/2016
1	Immunoglobulin M (IgM)IBA 08/2014
1	Oligonucleotide ProbesIBA 10/2013
1	Proline (L-Proline)FDA Link 06/2013
1	Histocompatibility Antigens Class IIIBA 01/2013
1	MineralsIBA 10/2012
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 05/2012
1	MucinsIBA 05/2012

Therapy/Procedure

8	Therapeutics 01/2022 - 07/2013
8	Immunotherapy 02/2021 - 09/2011
1	Transjugular Intrahepatic Portasystemic Shunt 09/2007